Mouse Anti-TMEM8A Recombinant Antibody (CBYJT-3531) (CBMAB-T2856-YJ)

Name: Mouse Anti-TMEM8A Recombinant Antibody (CBYJT-3531)
SKU: CBMAB-T2856-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3531

Application

Immunogen

Human TMEM8A transfected cells

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2, 0.2% BSA

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transmembrane Protein 8A

Introduction

TMEM8A (Transmembrane Protein 8A) is a Protein Coding gene. It is involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). It has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. It is required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). It is also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), it has no fusogenic activity (PubMed:26858401). An important paralog of TMEM8A is TMEM8B.

Entrez Gene ID

58986

UniProt ID

Q9HCN3

Alternative Names

Transmembrane Protein 8A; Transmembrane Protein 6; Post-Glycosylphosphatidylinositol Attachment To Proteins 6; Transmembrane Protein 8 (Five Membrane-Spanning Domains); GPI Processing Phospholipase A2; GPI-PLA2; TMEM6; TMEM8

Function

Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714).
Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684).
In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401).

Biological Process

Lipid metabolic process

Cellular Location

Cell membrane
Lysosome membrane

Topology

Extracellular: 35-545
Helical: 546-566
Cytoplasmic: 567-568
Helical: 569-589
Extracellular: 590-605
Helical: 606-626
Cytoplasmic: 627-629
Helical: 630-650
Extracellular: 651-653
Helical: 654-674
Cytoplasmic: 675-690
Helical: 691-711
Extracellular: 712-717
Helical: 718-738
Cytoplasmic: 739-771

PTM

Glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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