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Mouse Anti-TMEM8A Recombinant Antibody (CBYJT-3531) (CBMAB-T2856-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TMEM8A (Transmembrane Protein 8A). The antibody can be used for immunoassay techniques, such as FC.
See all TMEM8A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3531
Antibody Isotype
IgG2b, κ
Application
FC

Basic Information

Immunogen
Human TMEM8A transfected cells
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 0.2% BSA
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transmembrane Protein 8A
Introduction
TMEM8A (Transmembrane Protein 8A) is a Protein Coding gene. It is involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). It has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. It is required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). It is also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), it has no fusogenic activity (PubMed:26858401). An important paralog of TMEM8A is TMEM8B.
Entrez Gene ID
58986
UniProt ID
Q9HCN3
Alternative Names
Transmembrane Protein 8A; Transmembrane Protein 6; Post-Glycosylphosphatidylinositol Attachment To Proteins 6; Transmembrane Protein 8 (Five Membrane-Spanning Domains); GPI Processing Phospholipase A2; GPI-PLA2; TMEM6; TMEM8
Function
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714).
Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684).
In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401).
Biological Process
Lipid metabolic process
Cellular Location
Cell membrane
Lysosome membrane
Topology
Extracellular: 35-545
Helical: 546-566
Cytoplasmic: 567-568
Helical: 569-589
Extracellular: 590-605
Helical: 606-626
Cytoplasmic: 627-629
Helical: 630-650
Extracellular: 651-653
Helical: 654-674
Cytoplasmic: 675-690
Helical: 691-711
Extracellular: 712-717
Helical: 718-738
Cytoplasmic: 739-771
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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