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Mouse Anti-TNFRSF8 Recombinant Antibody (CBYJT-3866) (CBMAB-T3261-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNFRSF8 (TNF Receptor Superfamily Member 8). The antibody can be used for immunoassay techniques, such as WB, IHC, FC.
See all TNFRSF8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3866
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 19-379 of human TNFRSF8 (NP_001234) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 19-379

Target

Full Name
TNF receptor superfamily member 8
Introduction
TNFRSF8 is a member of the TNF-receptor superfamily. It is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with It, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
Entrez Gene ID
943
UniProt ID
P28908
Alternative Names
TNF Receptor Superfamily Member 8; Lymphocyte Activation Antigen CD30; CD30L Receptor; Ki-1 Antigen; D1S166E; CD30
Function
Receptor for TNFSF8/CD30L (PubMed:8391931).
May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).
Biological Process
Biological Process cellular response to mechanical stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of TRAIL production Source:UniProtKB1 Publication
Biological Process positive regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Cytoplasm
Topology
Extracellular: 19-385
Helical: 386-406
Cytoplasmic: 407-595
PTM
Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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