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Mouse Anti-TNNT2 Recombinant Antibody (CBT4786) (V2LY-0625-LY2767)


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Tested Data
Mouse Anti-TNNT2 Recombinant Antibody (CBT4786) (V2LY-0625-LY2767) in WB
Mouse Anti-TNNT2 Recombinant Antibody (CBT4786) (V2LY-0625-LY2767) in WB
Mouse Anti-TNNT2 Recombinant Antibody (CBT4786) (V2LY-0625-LY2767) in FC
Mouse Anti-TNNT2 Recombinant Antibody (CBT4786) (V2LY-0625-LY2767) in FC
Mouse Anti-TNNT2 Recombinant Antibody (CBT4786) (V2LY-0625-LY2767) in ELISA
Mouse Anti-TNNT2 Recombinant Antibody (CBT4786) (V2LY-0625-LY2767) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4786
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human troponin T2 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
7139
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process actin crosslink formation Source:Ensembl
Biological Process cardiac muscle contraction Source:CAFA1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process muscle filament sliding Source:UniProtKB2 Publications
Biological Process negative regulation of ATP-dependent activity Source:UniProtKB1 Publication
Biological Process positive regulation of ATP-dependent activity Source:UniProtKB2 Publications
Biological Process regulation of heart contraction Source:UniProtKB1 Publication
Biological Process regulation of muscle filament sliding speed Source:Ensembl
Biological Process response to calcium ion Source:UniProtKB1 Publication
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication
Cellular Location
cardiac myofibril
cardiac Troponin complex
cytosol
sarcomere
striated muscle thin filament
troponin complex
Involvement in disease
Cardiomyopathy, familial hypertrophic 2 (CMH2):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Cardiomyopathy, dilated 1D (CMD1D):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial restrictive 3 (RCM3):
A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
PTM
Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.
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For research use only. Not intended for any clinical use.

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