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Mouse Anti-TNPO3 Recombinant Antibody (CBYJT-4121) (CBMAB-T3562-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNPO3 (Transportin 3). The antibody can be used for immunoassay techniques, such as WB.
See all TNPO3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-4121
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human Transportin 3
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transportin 3
Introduction
TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. TNPO3 has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein.
Entrez Gene ID
Human23534
Mouse320938
Rat296954
UniProt ID
HumanQ9Y5L0
MouseQ6P2B1
RatD4AAM0
Alternative Names
Transportin 3; Limb Girdle Muscular Dystrophy 1F (Autosomal Dominant); Transportin-SR; Importin 12; TRN-SR; Imp12; IPO12
Function
Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914).
Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914).
Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518).
The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914).
Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914).
(Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PubMed:18722123, PubMed:21901095, PubMed:22398280, PubMed:29329553).
Required for a nuclear maturation step of HIV-1 prior to integration (PubMed:21901095, PubMed:22398280).
Biological Process
Protein import into nucleus
Cellular Location
Nucleus envelope
Cytoplasm
Localizes to the nuclear envelope and annulate lamellae, which consists in stacks of endoplasmic reticulum membranes containing a high density of nuclear pores.
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal dominant 2 (LGMDD2):
An autosomal dominant myopathy characterized by proximal muscle weakness primarily affecting the lower limbs, but also affecting the upper limbs in most patients. Affected individuals also have distal muscle weakness of the hands and lower leg muscles. The disease has generally a benign clinical course but some individuals with childhood or juvenile onset manifest severe widespread myopathy, leading to wheelchair dependency and respiratory insufficiency. Muscle biopsy shows dystrophic changes with abnormal nuclei, rimmed vacuoles, and filamentous inclusions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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