Rabbit Anti-TNXB Recombinant Antibody (SP230) (CBMAB-T3580-YJ)

Name: Rabbit Anti-TNXB Recombinant Antibody (SP230)
SKU: CBMAB-T3580-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

SP230

Application

IHC-P

Immunogen

Synthetic peptide within Human TN-X aa 1-100. The exact sequence is proprietary.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-100

More Infomation

Target

Full Name

TNXB Gene(Protein Coding) Tenascin XB

Introduction

TNXB is a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. TNXB is one of four genes in this cluster which have been duplicated. The duplicated copy of TNXB is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of TNXB is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively.

Entrez Gene ID

7148

UniProt ID

P22105

Alternative Names

Tenascin XB; Hexabrachion-Like Protein; TNXB1; TNXB2; HXBL; TN-X; TNX; XB; Growth-Inhibiting Protein 45; Tenascin XB1

Function

Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.

Biological Process

Biological Process actin cytoskeleton organization Source:UniProtKB
Biological Process cell adhesion Source:UniProtKB
Biological Process cell-cell adhesion Source:Ensembl
Biological Process cell-matrix adhesion Source:Ensembl
Biological Process collagen fibril organization Source:Ensembl
Biological Process collagen metabolic process Source:UniProtKB1 Publication
Biological Process elastic fiber assembly Source:UniProtKB1 Publication
Biological Process extracellular matrix organization Source:GO_Central1 Publication
Biological Process fatty acid metabolic process Source:Ensembl
Biological Process positive regulation of cell fate determination Source:ComplexPortal1 Publication
Biological Process positive regulation of collagen fibril organization Source:ComplexPortal1 Publication
Biological Process regulation of cell adhesion Source:GO_Central1 Publication
Biological Process regulation of cell differentiation Source:ComplexPortal1 Publication
Biological Process regulation of JUN kinase activity Source:Ensembl
Biological Process triglyceride metabolic process Source:Ensembl

Cellular Location

Secreted, extracellular space, extracellular matrix

Involvement in disease

Ehlers-Danlos syndrome, classic-like (EDSCLL):
A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSCLL patients lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos syndrome. Delayed wound healing is only present in a subset of patients. EDSCLL inheritance is autosomal recessive.
Vesicoureteral reflux 8 (VUR8):
A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TNXB Matched Antibody Pair (1249) (CAT#: APMAB-1249LY)

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TNXB Matched Antibody Pair (1249) (CAT#: APMAB-1249LY)

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Rat Anti-Tnxb Recombinant Antibody (CBYJT-4135) (CAT#: CBMAB-T3582-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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