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Rat Anti-TOX Recombinant Antibody (TXRX10) (CBMAB-T3700-YJ)

Provided herein is a Rat monoclonal antibody, which binds to TOX (Thymocyte Selection Associated High Mobility Group Box). The antibody can be used for immunoassay techniques, such as IP, WB.
See all TOX antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
TXRX10
Antibody Isotype
IgG2a, κ
Application
IP, WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Thymocyte Selection Associated High Mobility Group Box
Introduction
TOX contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. TOX may function to regulate T-cell development.
Entrez Gene ID
Human9760
Mouse252838
UniProt ID
HumanO94900
MouseQ66JW3
Alternative Names
Thymocyte Selection Associated High Mobility Group Box; Thymus High Mobility Group Box Protein TOX; Thymocyte Selection-Associated High Mobility Group Box Protein TOX; KIAA0808; TOX1
Function
Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity).
Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity).
Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity).
May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:21126536) (By similarity).
Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity).
Biological Process
Biological Process CD4-positive, alpha-beta T cell lineage commitment Source:UniProtKB
Biological Process CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment Source:UniProtKB
Biological Process CD8-positive, alpha-beta T cell lineage commitment Source:UniProtKB
Biological Process cerebral cortex neuron differentiation Source:UniProtKB
Biological Process chromatin organization Source:UniProtKB-KW
Biological Process leukocyte differentiation Source:GO_Central1 Publication
Biological Process lymph node development Source:Ensembl
Biological Process natural killer cell differentiation Source:UniProtKB1 Publication
Biological Process NK T cell lineage commitment Source:UniProtKB
Biological Process Peyer's patch development Source:Ensembl
Biological Process positive regulation of DNA demethylation Source:UniProtKB
Biological Process positive regulation of natural killer cell differentiation Source:Ensembl
Biological Process positive regulation of neural precursor cell proliferation Source:UniProtKB
Biological Process positive regulation of neuron projection development Source:UniProtKB
Biological Process regulation of positive thymic T cell selection Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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