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Mouse Anti-TOX3 Recombinant Antibody (CBYJT-4237) (CBMAB-T3702-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TOX3 (TOX High Mobility Group Box Family Member 3). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all TOX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4237
Antibody Isotype
IgG1, κ
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TOX3
Introduction
TOX3 contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer.
Entrez Gene ID
27324
UniProt ID
O15405
Alternative Names
TOX High Mobility Group Box Family Member 3; CAG Trinucleotide Repeat-Containing Gene F9 Protein; Trinucleotide Repeat-Containing Gene 9 Protein; TNRC9; CAGF9; Trinucleotide Repeat Containing 9
Function
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of neuron apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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