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Mouse Anti-TPM4 Recombinant Antibody (4E4-1D2) (CBMAB-T3841-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TPM4 (Tropomyosin 4). The antibody can be used for immunoassay techniques, such as ELISA, IF, IHC-P, WB.
See all TPM4 antibodies
Published Data
Fig.1 Loss of Tpm4 isoforms affects cell migration and invasion.
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Fig.2 ALK subcellular localization (A) and FISH evaluations (B–C) in IMT case 1: Strong cytoplasmic ALK staining is evident in the spindle cells, whereas ALK is undetectable in the intervening inflammatory cells (A).
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Fig.3 TPM4 insufficiency results in altered platelet morphology.
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Fig.4 The function of human platelets is mildly affected by reduced TPM4 expression.
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Fig.5 TPM4 insufficiency results in altered platelet morphology.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E4-1D2
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tropomyosin 4
Introduction
TPM4 is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament.
Entrez Gene ID
7171
UniProt ID
P67936
Alternative Names
Tropomyosin 4; TM30p1; Epididymis Secretory Protein Li 108; Tropomyosin Alpha-4 Chain; Tropomyosin-4; HEL-S-108
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity).
Binds calcium (PubMed:1836432).
Biological Process
Biological Process actin filament organization Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process osteoblast differentiation Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Associates with F-actin stress fibers.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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