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Mouse Anti-TPRKB Recombinant Antibody (CBFYC-3207) (CBMAB-C3284-FY)

This product is mouse antibody that recognizes TPRKB. The antibody CBFYC-3207 can be used for immunoassay techniques such as: Dot.
See all TPRKB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-3207
Antibody Isotype
IgG2b
Application
Dot

Basic Information

Immunogen
Recombinant Human Tp53Rk Binding Protein (Tprkb)
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 1% BSA, pH 7.4
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TPRKB Gene(Protein Coding) TP53RK Binding Protein
Introduction
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t6A activity of the complex. TPRKB is not required for tRNA modification.
Entrez Gene ID
51002
UniProt ID
Q9Y3C4
Alternative Names
CGI121; GAMOS5; CGI-121
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828).
The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828).
TPRKB acts as an allosteric effector that regulates the t6A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).
Biological Process
Biological Process telomere maintenance via recombination Source:GO_Central1 Publication
Biological Process tRNA threonylcarbamoyladenosine modification Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Nucleus
Involvement in disease
Galloway-Mowat syndrome 5 (GAMOS5):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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