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Mouse Anti-TRAF4 Recombinant Antibody (CBYJT-4515) (CBMAB-T4020-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRAF4 (TNF Receptor Associated Factor 4). The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all TRAF4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4515
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRAF4 Gene(Protein Coding) TNF Receptor Associated Factor 4
Introduction
TRAF4 is a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. TRAF4 has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. TRAF4 thus, is thought to be involved in the oxidative activation of MAPK8/JNK.
Entrez Gene ID
9618
UniProt ID
Q9BUZ4
Alternative Names
TNF Receptor Associated Factor 4; Cysteine-Rich Domain Associated With RING And Traf Domains Protein 1; Metastatic Lymph Node Gene 62 Protein; RING Finger Protein 83; MLN 62; CART1; MLN62
Function
Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522).
Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854).
Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633).
Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935).
In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522).
Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity).
Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273).
Biological Process
Biological Process activation of NF-kappaB-inducing kinase activity Source:InterPro
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process innate immune response Source:UniProtKB-KW
Biological Process positive regulation of JNK cascade Source:UniProtKB1 Publication
Biological Process positive regulation of protein kinase activity Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB-UniPathway
Biological Process regulation of apoptotic process Source:InterPro
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process respiratory gaseous exchange by respiratory system Source:Ensembl
Biological Process respiratory tube development Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, perinuclear region
Cell junction, tight junction
Cell membrane
Cytoplasm, cytoskeleton
PTM
Polyubiquitinated, leading to its proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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