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Mouse Anti-TRAK1 Recombinant Antibody (CBYJT-4541) (CBMAB-T4049-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRAK1 (Trafficking Kinesin Protein 1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TRAK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4541
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
TRAK1 (NP_055780.2, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MSLRDKGGEE ECFEYDCQDE ERKPTHRQHD TQDLLEEVLC AERVGQMTKT YNDIDAVTRL LEEKERDLEL AARIGQSLLK KNKTLTERNE LLEEQVEHIR E
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-101

Target

Full Name
Trafficking Kinesin Protein 1
Introduction
TRAK1 (Trafficking Kinesin Protein 1) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to TRAK1 include GABA receptor binding. An important paralog of TRAK1 is TRAK2.
Entrez Gene ID
22906
UniProt ID
Q9UPV9
Alternative Names
Trafficking Kinesin Protein 1; O-Linked N-Acetylglucosamine Transferase Interacting Protein 106; 106 KDa O-GlcNAc Transferase-Interacting Protein; Trafficking Protein, Kinesin Binding 1; OIP106; OGT(O Glc NAc Transferase) Interacting Protein 106 KDa; OGT(O-Glc-NAc Transferase)-Interacting Protein 106 KDa
Function
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823).
Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978).
TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).
Biological Process
Biological Process anterograde axonal transport of mitochondrion Source:GO_Central1 Publication
Biological Process endosome to lysosome transport Source:UniProtKB1 Publication
Biological Process mitochondrion distribution Source:GO_Central1 Publication
Biological Process neurogenesis Source:GO_Central1 Publication
Biological Process protein O-linked glycosylation Source:UniProtKB
Biological Process protein targeting Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process vesicle transport along microtubule Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Mitochondrion
Early endosome
Endosome
Mitochondrion membrane
Cytoplasm, cell cortex
Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823).
Colocalizes with MGARP at the mitochondria (PubMed:19528298).
Involvement in disease
Developmental and epileptic encephalopathy 68 (DEE68):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE68 is an autosomal recessive form characterized by onset of twitching and/or myoclonic jerks in infancy. The disorder progresses to refractory generalized tonic-clonic seizures, often resulting in status epilepticus, loss of developmental milestones, and early death. Other features include delayed development, axial hypotonia, spasticity of the limbs, and clonus.
PTM
O-glycosylated (PubMed:24995978, PubMed:12435728).
Glycosylated by OGT; glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT (PubMed:24995978).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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