Mouse Anti-TRAPPC2 Recombinant Antibody (CBYJT-4557) (CBMAB-T4070-YJ)

Name: Mouse Anti-TRAPPC2 Recombinant Antibody (CBYJT-4557)
SKU: CBMAB-T4070-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4557

Application

ELISA, WB

Immunogen

Full length recombinant corresponding to aa1-141 from human TRAPPC2 (AAH16915) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-141

More Infomation

Target

Full Name

trafficking protein particle complex 2

Introduction

TRAPPC2 is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene can cause spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y.

Entrez Gene ID

6399

UniProt ID

P0DI81

Alternative Names

Trafficking Protein Particle Complex 2; Sedlin; SEDL; Trafficking Protein Particle Complex Subunit 2; Spondyloepiphyseal Dysplasia, Late; TRAPPC2P1

Function

Prevents transcriptional repression and induction of cell death by ENO1 (By similarity).
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Biological Process

Biological Process COPII vesicle coating Source:ComplexPortal1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:GO_Central1 Publication
Biological Process skeletal system development Source:UniProtKB1 Publication
Biological Process vesicle coating Source:ComplexPortal1 Publication
Biological Process vesicle tethering Source:ComplexPortal1 Publication

Cellular Location

Cytoplasm, perinuclear region
Endoplasmic reticulum-Golgi intermediate compartment
Nucleus
Cytoplasm
Localized in perinuclear granular structures.

Involvement in disease

Spondyloepiphyseal dysplasia tarda (SEDT):
X-linked recessive disorder of endochondral bone formation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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