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  • Mouse Anti-TRDN Recombinant Antibody (IIG12)

Mouse Anti-TRDN Recombinant Antibody (IIG12) (CBMAB-T4111-YJ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
IIG12
Application
BL, ICC, IF, IHC, IP, WB
Immunogen
Rabbit skeletal muscle triads
Specificity
Rabbit, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Triadin
Introduction
TRDN contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction (PubMed:19398037, PubMed:17846166 and PubMed:7721813). TRDN is required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. It is required for normal skeletal muscle strength. TRDN plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity).
Entrez Gene ID
Mouse76757
Rabbit100009519
UniProt ID
MouseE9Q9K5
RabbitQ28820
Function
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity).
Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Biological Process
Biological Process cellular calcium ion homeostasis Source:BHF-UCL
Biological Process cytoplasmic microtubule organization Source:BHF-UCL
Biological Process endoplasmic reticulum membrane organization Source:BHF-UCL
Biological Process establishment of localization in cell Source:Ensembl
Biological Process heart contraction Source:BHF-UCL1 Publication
Biological Process muscle contraction Source:ProtInc1 Publication
Biological Process negative regulation of ryanodine-sensitive calcium-release channel activity Source:BHF-UCL1 Publication
Biological Process positive regulation of cell communication by electrical coupling involved in cardiac conduction Source:BHF-UCL
Biological Process positive regulation of ryanodine-sensitive calcium-release channel activity Source:BHF-UCL
Biological Process regulation of cardiac muscle cell membrane potential Source:BHF-UCL
Biological Process regulation of cell communication by electrical coupling Source:BHF-UCL1 Publication
Biological Process regulation of release of sequestered calcium ion into cytosol Source:BHF-UCL1 Publication
Biological Process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source:BHF-UCL
Biological Process release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source:BHF-UCL
Biological Process response to bacterium Source:Ensembl
Cellular Location
Cell membrane
Sarcoplasmic reticulum membrane
Involvement in disease
Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5):
An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, or sudden death after physical activity or emotional stress. Some patients have muscle weakness. CPVT5 inheritance is autosomal recessive.
Topology
Cytoplasmic: 1-47
Helical: 48-68
Lumenal: 69-729
PTM
Phosphorylated by CaMK2.
N-glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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