Mouse Anti-TRIM22 Recombinant Antibody (CBYJT-4700) (CBMAB-T4236-YJ)

Name: Mouse Anti-TRIM22 Recombinant Antibody (CBYJT-4700)
SKU: CBMAB-T4236-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4700

Application

WB, IHC

Immunogen

Human recombinant protein fragment corresponding to amino acids 61-406 of human TRIM22(NP_006065) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 61-406

More Infomation

Target

Full Name

tripartite motif containing 22

Introduction

TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM22 localizes to the cytoplasm and its expression is induced by interferon. It down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.

Entrez Gene ID

10346

UniProt ID

Q8IYM9

Alternative Names

Tripartite Motif Containing 22; RING-Type E3 Ubiquitin Transferase TRIM22; Tripartite Motif-Containing Protein 22; 50 KDa-Stimulated Trans-Acting Factor; RING Finger Protein 94; Staf-50; STAF50; RNF94; Stimulated Trans-Acting Factor (50 KDa)

Function

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

Biological Process

Biological Process defense response to virus Source:UniProtKB-KW
Biological Process immune response Source:ProtInc1 Publication
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of autophagy Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of DNA-templated transcription Source:ProtInc1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of protein localization Source:UniProtKB1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication
Biological Process response to virus Source:ProtInc1 Publication

Cellular Location

Cytoplasm
Nucleus
Nucleus speckle
Nucleus, Cajal body
Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.

PTM

Auto-ubiquitinated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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