Mouse Anti-TRIM23 Recombinant Antibody (2H4) (CBMAB-A9504-LY)

Name: Mouse Anti-TRIM23 Recombinant Antibody (2H4)
SKU: CBMAB-A9504-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2H4

Application

sELISA, ELISA

Immunogen

TRIM23 (AAH22510, 1 a.a. ~ 574 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TRIM23 Gene(Protein Coding) Tripartite Motif Containing 23

Introduction

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq]

Entrez Gene ID

373

UniProt ID

P36406

Alternative Names

ARD1; ARFD1; RNF46

Function

Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).
(Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.

Biological Process

Biological Process innate immune response Source:UniProtKB-KW
Biological Process intracellular protein transport Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:HGNC-UCL1 Publication
Biological Process vesicle-mediated transport Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Endomembrane system
Golgi apparatus membrane
Lysosome membrane
Membrane-associated with the Golgi complex and lysosomal structures.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TRIM23 Matched Antibody Pair (1275) (CAT#: APMAB-1275LY)

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TRIM23 Matched Antibody Pair (1275) (CAT#: APMAB-1275LY)

Mouse Anti-TRIM23 Recombinant Antibody (CBYJT-4703) (CAT#: CBMAB-T4239-YJ)

Mouse Anti-TRIM23 Recombinant Antibody (CBYJT-4704) (CAT#: CBMAB-T4240-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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