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Mouse Anti-TRIM23 Recombinant Antibody (CBYJT-4703) (CBMAB-T4239-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM23 (Tripartite Motif Containing 23). The antibody can be used for immunoassay techniques, such as ELISA.
See all TRIM23 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4703
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
TRIM23 (AAH22510, 1aa-574aa) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-574

Target

Full Name
TRIM23 Gene(Protein Coding) Tripartite Motif Containing 23
Introduction
TRIM23 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. It localizes to lysosomes and the Golgi apparatus. It functions in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation.
Entrez Gene ID
373
UniProt ID
P36406
Alternative Names
Tripartite Motif Containing 23; ADP-Ribosylation Factor Domain-Containing Protein 1; ADP-Ribosylation Factor Domain Protein 1, 64kDa; RING-Type E3 Ubiquitin Transferase TRIM23; Tripartite Motif-Containing Protein 23; GTP-Binding Protein ARD-1; RING Finger Protein 46; ARFD1
Function
Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).
(Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.
Biological Process
Biological Process innate immune response Source:UniProtKB-KW
Biological Process intracellular protein transport Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:HGNC-UCL1 Publication
Biological Process vesicle-mediated transport Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Endomembrane system
Golgi apparatus membrane
Lysosome membrane
Membrane-associated with the Golgi complex and lysosomal structures.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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