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Mouse Anti-TRIM26 Recombinant Antibody (CBYJT-4724) (CBMAB-T4261-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM26 (Tripartite Motif Containing 26). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TRIM26 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4724
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa146-241 from human TRIM26 (NP_003440) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 146-241

Target

Full Name
tripartite motif-containing 26
Introduction
TRIM26 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to cytoplasmic bodies. Although the function of it is unknown, the RING domain suggests that It may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6.
Entrez Gene ID
7726
UniProt ID
Q12899
Alternative Names
Tripartite Motif Containing 26; Zinc Finger Protein 173; RING Finger Protein 95; Acid Finger Protein; ZNF173; RNF95
Function
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.
Biological Process
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of viral entry into host cell Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process suppression of viral release by host Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Viral infection mediates TRIM26 nuclear translocation.
PTM
Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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