Sign in or Register   Sign in or Register
  |  

Mouse Anti-TRIP11 Recombinant Antibody (CBYJT-4851) (CBMAB-T4396-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIP11 (Thyroid Hormone Receptor Interactor 11). The antibody can be used for immunoassay techniques, such as IP, WB.
See all TRIP11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4851
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1099-1372

Target

Full Name
Thyroid Hormone Receptor Interactor 11
Introduction
TRIP11 was identified based on the interaction of its protein product with thyroid hormone receptor beta. TRIP11 is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to function in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in TRIP11 cause achondrogenesis type IA.
Entrez Gene ID
9321
UniProt ID
Q15643
Alternative Names
Thyroid Hormone Receptor Interactor 11; Clonal Evolution-Related Gene On Chromosome 14 Protein; Golgi-Associated Microtubule-Binding Protein 210; TR-Interacting Protein 11; GMAP-210; TRIP230; TRIP-11
Function
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324).
It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001).
Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.
Biological Process
Biological Process cartilage development Source:UniProtKB1 Publication
Biological Process chondrocyte differentiation involved in endochondral bone morphogenesis Source:Ensembl
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:GO_Central1 Publication
Biological Process Golgi organization Source:GO_Central1 Publication
Biological Process Golgi ribbon formation Source:UniProtKB1 Publication
Biological Process inner ear receptor cell stereocilium organization Source:Ensembl
Biological Process protein glycosylation Source:Ensembl
Biological Process transcription by RNA polymerase II Source:ProtInc1 Publication
Biological Process ventricular septum development Source:Ensembl
Biological Process vesicle tethering to Golgi Source:UniProtKB1 Publication
Cellular Location
Golgi apparatus, cis-Golgi network membrane
Cytoplasm, cytoskeleton
Endoplasmic reticulum-Golgi intermediate compartment membrane
Associates with the ends of centrosome-nucleated microtubules.
Involvement in disease
Achondrogenesis 1A (ACG1A):
A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues.
Odontochondrodysplasia 1 (ODCD1):
An autosomal recessive disorder of skeletal and dental development characterized by mesomelic shortening of tubular bones, ligamentous laxity, scoliosis, and dentinogenesis imperfecta involving both primary and secondary dentition. Radiologic features include trident pelvis, posteriorly flattened vertebrae, and brachydactyly with cone-shaped epiphyses.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRIP11 Recombinant Antibody (CBYJT-4851)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare