Sign in or Register   Sign in or Register
  |  

Mouse Anti-TRIP4 Recombinant Antibody (F-8) (CBMAB-A4898-YC)

Provided herein is a Mouse monoclonal antibody against Human Thyroid Hormone Receptor Interactor 4. The antibody can be used for immunoassay techniques, such as WB, IP, IF, IHC-P, ELISA.
See all TRIP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
F-8
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Thyroid Hormone Receptor Interactor 4
Introduction
TRIP4 is a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. Th
Entrez Gene ID
Human9325
Mouse56404
Rat315769
UniProt ID
HumanQ15650
MouseQ9QXN3
RatB5DEP5
Alternative Names
Thyroid Hormone Receptor Interactor 4; Thyroid Receptor-Interacting Protein 4; TR-Interacting Protein 4; Zinc Finger, C2HC5-Type; TRIP-4; ASC-1; Activating Signal Cointegrator 1;
Function
Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498).
Also involved in androgen receptor transactivation (By similarity).
Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347).
May play a role in the development of neuromuscular junction (PubMed:26924529).
May play a role in late myogenic differentiation (By similarity).
Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016).
Biological Process
Biological Process intracellular estrogen receptor signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of myoblast differentiation Source:UniProtKB
Biological Process rescue of stalled ribosome Source:UniProtKB1 Publication
Biological Process ribosome disassembly Source:ComplexPortal1 Publication
Biological Process ribosome-associated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process toxin transport Source:Ensembl
Cellular Location
Nucleus
Cytoplasm, cytosol
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasmic under conditions of serum deprivation (PubMed:10454579).
Colocalizes with NEK6 in the centrosome (PubMed:20873783).
Involvement in disease
Spinal muscular atrophy with congenital bone fractures 1 (SMABF1):
An autosomal recessive neuromuscular disorder characterized by prenatal-onset spinal muscular atrophy, multiple congenital contractures consistent with arthrogryposis multiplex congenita, respiratory distress, and congenital bone fractures.
Muscular dystrophy, congenital, Davignon-Chauveau type (MDCDC):
An autosomal recessive, severe congenital muscular dystrophy characterized by neonatal onset of muscle weakness predominantly involving axial muscles, life-threatening respiratory failure, skin abnormalities and joint hyperlaxity without contractures. Muscle biopsies show multi-minicores, caps and dystrophic lesions.
PTM
Phosphorylated by NEK6.
Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRIP4 Recombinant Antibody (F-8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare