Mouse Anti-TRMT1 Recombinant Antibody (CBYJT-4865) (CBMAB-T4411-YJ)

Name: Mouse Anti-TRMT1 Recombinant Antibody (CBYJT-4865)
SKU: CBMAB-T4411-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4865

Application

WB, IF

Immunogen

Full length human recombinant protein of human TRMU (NP_060476) produced in HEK293T cell

Specificity

Human, Mouse, Dog, Monkey

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TRNA Methyltransferase 1

Introduction

TRMT1 is a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in TRMT1 have been implicated in autosomal recessive intellectual disorder (ARID).

Entrez Gene ID

Human	55621
Mouse	212528
Dog	476692
Monkey	718227

UniProt ID

Human	Q9NXH9
Mouse	Q3TX08
Dog	A0A8I3Q4I4
Monkey	F6RHQ5

Alternative Names

TRNA Methyltransferase 1; TRNA 2, 2-Dimethylguanosine-26 Methyltransferase; TRNA(Guanine-26, N(2)-N(2)) Methyltransferase; TRNA(M(2, 2)G26)Dimethyltransferase; N(2), N(2)-Dimethylguanosine TRNA Methyltransferase; TRNA Methyltransferase 1 Homolog (S. Cerevisiae); TRNA (Guanine(26)-N(2))-Dimethyltransferase

Function

Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

Biological Process

Biological Process tRNA modification Source:Reactome
Biological Process tRNA N2-guanine methylation Source:GO_Central1 Publication

Cellular Location

nucleoplasm
nucleus

Involvement in disease

Intellectual developmental disorder, autosomal recessive 68 (MRT68):
A form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TRMT1 Recombinant Antibody (CBYJT-4867) (CAT#: CBMAB-T4413-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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