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Mouse Anti-TRMU Recombinant Antibody (CBYJT-4883) (CBMAB-T4429-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRMU (TRNA 5-Methylaminomethyl-2-Thiouridylate Methyltransferase). The antibody can be used for immunoassay techniques, such as WB, IF.
See all TRMU antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey, Mouse
Clone
CBYJT-4883
Antibody Isotype
IgG2a
Application
WB, IF

Basic Information

Immunogen
Full length human recombinant protein of human TRMU(NP_060476) produced in HEK293T cell
Specificity
Human, Dog, Monkey, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tRNA-specific 2-thiouridylase MnmA
Introduction
TRMU is a mitochondrial tRNA-modifying enzyme. TRMU catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in TRMU may cause transient infantile liver failure. Polymorphisms in TRMU may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations.
Entrez Gene ID
Human55687
Mouse72026
Dog481204
Monkey714268
UniProt ID
HumanO75648
MouseQ9DAT5
DogA0A8I3N2T0
MonkeyF6R1K4
Alternative Names
TRNA 5-Methylaminomethyl-2-Thiouridylate Methyltransferase; MTO2 Homolog; TRMT1; MTU1; Mitochondrial 5-Methylaminomethyl-2-Thiouridylate-Methyltransferase; TRNA (5-Methylaminomethyl-2-Thiouridylate)-Methyltransferase; Mitochondrial TRNA-Specific 2-Thiouridylase 1
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Biological Process
Biological Process tRNA wobble position uridine thiolation Source:GO_Central1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Deafness, aminoglycoside-induced (DFNI):
A form of sensorineural deafness characterized by moderate-to-profound hearing loss and mitochondrial inheritance. It is induced by exposure to aminoglycosides.
Liver failure, infantile, transient (LFIT):
A transient disorder of hepatic function characterized by elevated liver enzymes, jaundice, vomiting, coagulopathy, hyperbilirubinemia, increased serum lactate. Patients who survive the initial acute episode can recover, show normal development and have no recurrence.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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