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Mouse Anti-TRNT1 Recombinant Antibody (CBYJT-4885) (CBMAB-T4431-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRNT1 (TRNA Nucleotidyl Transferase 1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TRNT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4885
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-406 from human TRNT1 (AAH12537) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-406

Target

Full Name
tRNA nucleotidyl transferase, CCA-adding, 1
Introduction
TRNT1 is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This necessary enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay.
Entrez Gene ID
51095
UniProt ID
Q96Q11
Alternative Names
TRNA Nucleotidyl Transferase 1; TRNA Nucleotidyl Transferase, CCA-Adding, 1; ATP(CTP):TRNA Nucleotidyltransferase; TRNA CCA Nucleotidyl Transferase 1; Mt TRNA CCA-Pyrophosphorylase; Mt TRNA CCA-Diphosphorylase; Mt TRNA Adenylyltransferase; Mt CCA-Adding Enzyme; CCA-Adding Enzyme; Mitochondrial TRNA Nucleotidyl Transferase, CCA-Adding
Function
Isoform 1
Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.
Isoform 2
Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).
Biological Process
Biological Process mitochondrial tRNA 3'-end processing Source:UniProtKB1 Publication
Biological Process tRNA 3'-end processing Source:Reactome
Biological Process tRNA 3'-terminal CCA addition Source:UniProtKB1 Publication
Biological Process tRNA processing Source:GO_Central1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD):
An autosomal recessive disease characterized by severe sideroblastic anemia with onset in the neonatal period or infancy, recurrent periodic fevers without an infectious etiology, B-cell lymphopenia and hypogammaglobulinemia. Affected individuals show delayed psychomotor development with variable neurodegeneration. Additional variable features include sensorineural hearing loss, retinitis pigmentosa, nephrocalcinosis, and cardiomyopathy.
Retinitis pigmentosa and erythrocytic microcytosis (RPEM):
An autosomal recessive disease characterized by retinitis pigmentosa, red blood cell microcytosis and anisocytosis with mild anemia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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