Mouse Anti-TRPM1 Recombinant Antibody (CBFYM-3170) (CBMAB-M3367-FY)

Name: Mouse Anti-TRPM1 Recombinant Antibody (CBFYM-3170)
SKU: CBMAB-M3367-FY
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBFYM-3170

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TRPM1 Gene(Protein Coding)

Transient Receptor Potential Cation Channel Subfamily M Member 1

Introduction

This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

4308

UniProt ID

Q7Z4N2

Alternative Names

Transient Receptor Potential Cation Channel Subfamily M Member 1; Long Transient Receptor Potential Channel 1; Melastatin-1; LTRPC1; MLSN1; Transient Receptor Potential Cation Channel, Subfamily M, Member 1

Function

Forms nonselective divalent cation-conducting channels which mediate the influx of Na2+, Ca2+, Mg2+, Mn2+, Ba2+, and Ni2+ into the cytoplasm, leading to membrane depolarization (PubMed:19436059, PubMed:21278253).
Impermeable to zinc ions (PubMed:21278253).
In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253).
Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity).
May act as a spontaneously active, calcium-permeable plasma membrane channel.

Biological Process

Biological Process calcium ion import across plasma membrane Source:UniProtKB1 Publication
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process calcium ion transport into cytosol Source:GO_Central1 Publication
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular response to light stimulus Source:UniProtKB1 Publication
Biological Process G protein-coupled glutamate receptor signaling pathway Source:UniProtKB1 Publication
Biological Process protein tetramerization Source:InterPro
Biological Process visual perception Source:UniProtKB1 Publication

Cellular Location

Cell membrane
Endoplasmic reticulum membrane
Cell projection, axon

Involvement in disease

Night blindness, congenital stationary, 1C (CSNB1C):
A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.

Topology

Cytoplasmic: 1-830
Helical: 831-851
Extracellular: 852-897
Helical: 898-918
Cytoplasmic: 919-928
Helical: 929-949
Extracellular: 950-961
Helical: 962-982
Cytoplasmic: 983-1054
Helical: 1055-1075
Extracellular: 1076-1105
Helical: 1106-1126
Cytoplasmic: 1127-1603

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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