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Mouse Anti-TRPM1 Recombinant Antibody (CBFYM-3170) (CBMAB-M3367-FY)

This product is mouse antibody that recognizes TRPM1. The antibody CBFYM-3170 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all TRPM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3170
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRPM1 Gene(Protein Coding)


Transient Receptor Potential Cation Channel Subfamily M Member 1
Introduction
This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
4308
UniProt ID
Q7Z4N2
Alternative Names
Transient Receptor Potential Cation Channel Subfamily M Member 1; Long Transient Receptor Potential Channel 1; Melastatin-1; LTRPC1; MLSN1; Transient Receptor Potential Cation Channel, Subfamily M, Member 1
Function
Forms nonselective divalent cation-conducting channels which mediate the influx of Na2+, Ca2+, Mg2+, Mn2+, Ba2+, and Ni2+ into the cytoplasm, leading to membrane depolarization (PubMed:19436059, PubMed:21278253).
Impermeable to zinc ions (PubMed:21278253).
In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253).
Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity).
May act as a spontaneously active, calcium-permeable plasma membrane channel.
Biological Process
Biological Process calcium ion import across plasma membrane Source:UniProtKB1 Publication
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process calcium ion transport into cytosol Source:GO_Central1 Publication
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular response to light stimulus Source:UniProtKB1 Publication
Biological Process G protein-coupled glutamate receptor signaling pathway Source:UniProtKB1 Publication
Biological Process protein tetramerization Source:InterPro
Biological Process visual perception Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
Cell projection, axon
Involvement in disease
Night blindness, congenital stationary, 1C (CSNB1C):
A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
Topology
Cytoplasmic: 1-830
Helical: 831-851
Extracellular: 852-897
Helical: 898-918
Cytoplasmic: 919-928
Helical: 929-949
Extracellular: 950-961
Helical: 962-982
Cytoplasmic: 983-1054
Helical: 1055-1075
Extracellular: 1076-1105
Helical: 1106-1126
Cytoplasmic: 1127-1603
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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