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Rabbit Anti-TRPM5 Recombinant Antibody (BA0336) (CBMAB-0886CQ)

This product is a rabbit antibody that recognizes TRPM5. The antibody BA0336 can be used for immunoassay techniques such as: WB.
See all TRPM5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0336
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide from residues near the N terminus of Human TRPM5
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transient Receptor Potential Cation Channel Subfamily M Member 5
Introduction
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Entrez Gene ID
Human29850
Mouse56843
Rat365391
UniProt ID
HumanQ9NZQ8
MouseQ9JJH7
RatF1LMD7
Alternative Names
MTR1; LTRPC5
Function
Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process regulation of ion transmembrane transport Source:UniProtKB-KW
Biological Process sensory perception of taste Source:InterPro
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-646
Helical: 647-667
Extracellular: 668-733
Helical: 734-754
Cytoplasmic: 755-811
Helical: 812-832
Extracellular: 833-835
Helical: 836-856
Cytoplasmic: 857-872
Helical: 873-893
Extracellular: 894-954
Helical: 955-975
Cytoplasmic: 976-1165
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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