Rabbit Anti-TRPM5 Recombinant Antibody (BA0336) (CBMAB-0886CQ)

Name: Rabbit Anti-TRPM5 Recombinant Antibody (BA0336)
SKU: CBMAB-0886CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

BA0336

Application

Immunogen

Synthetic peptide from residues near the N terminus of Human TRPM5

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transient Receptor Potential Cation Channel Subfamily M Member 5

Introduction

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

Entrez Gene ID

Human	29850
Mouse	56843
Rat	365391

UniProt ID

Human	Q9NZQ8
Mouse	Q9JJH7
Rat	F1LMD7

Alternative Names

MTR1; LTRPC5

Function

Voltage-modulated Ca2+-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na+, K+ and Cs+ ions equally well. Activated directly by increases in intracellular Ca2+, but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca2+. Also activated by a fast intracellular Ca2+ increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

Biological Process

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process regulation of ion transmembrane transport Source:UniProtKB-KW
Biological Process sensory perception of taste Source:InterPro

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-646
Helical: 647-667
Extracellular: 668-733
Helical: 734-754
Cytoplasmic: 755-811
Helical: 812-832
Extracellular: 833-835
Helical: 836-856
Cytoplasmic: 857-872
Helical: 873-893
Extracellular: 894-954
Helical: 955-975
Cytoplasmic: 976-1165

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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