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Mouse Anti-TRPV5 Recombinant Antibody (CBFYE-1675) (CBMAB-E2346-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1675
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transient receptor potential cation channel, subfamily V, member 5
Introduction
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
Entrez Gene ID
56302
UniProt ID
Q9NQA5
Alternative Names
Transient Receptor Potential Cation Channel Subfamily V Member 5; Epithelial Calcium Channel 1; Calcium Transport Protein 2; Osm-9-Like TRP Channel 3; OTRPC3; ECAC1
Function
Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590).
Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules (By similarity).
The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590).
A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity).
Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
Biological Process
Biological Process calcium ion homeostasis Source:UniProtKB
Biological Process calcium ion import across plasma membrane Source:UniProtKB1 Publication
Biological Process calcium ion transmembrane transport Source:UniProtKB1 Publication
Biological Process calcium ion transport Source:UniProtKB
Biological Process protein homotetramerization Source:UniProtKB
Biological Process regulation of urine volume Source:UniProtKB
Cellular Location
Apical cell membrane
Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity).
The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590).
Topology
Cytoplasmic: 1-327
Helical: 328-348
Extracellular: 349-385
Helical: 386-408
Cytoplasmic: 409-419
Helical: 420-442
Extracellular: 443-448
Helical: 449-469
Cytoplasmic: 470-492
Helical: 493-513
Pore-forming: 524-544
Helical: 557-577
Cytoplasmic: 578-729
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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