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Mouse Anti-TSN Recombinant Antibody (CBYJT-5052) (CBMAB-T4628-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TSN (Translin). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all TSN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5052
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-51 of human TSN(NP_004613) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-51

Target

Full Name
Translin
Introduction
TSN is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. TSN, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation.
Entrez Gene ID
7247
UniProt ID
Q15631
Alternative Names
Translin; Recombination Hotspot Associated Factor; Component 3 Of Promoter Of RISC; C3PO; Recombination Hotspot-Binding Protein; Testis Brain-RNA Binding Protein
Function
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
Biological Process
Biological Process DNA recombination Source:ProtInc1 Publication
Biological Process siRNA processing Source:ComplexPortal1 Publication
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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