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Mouse Anti-TSPYL1 Recombinant Antibody (CBYJT-5096) (CBMAB-T4674-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TSPYL1 (TSPY Like 1). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all TSPYL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5096
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TSPY-like 1
Introduction
TSPYL1 is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene can cause sudden infant death with dysgenesis of the testes syndrome (SIDDT).
Entrez Gene ID
UniProt ID
Alternative Names
TSPY Like 1; TSPY-Like Protein 1; TSPYL; Testis-Specific Y-Encoded-Like Protein 1; TSPY-Like
Biological Process
Biological Process nucleosome assembly Source:InterPro
Cellular Location
Nucleus, nucleolus
Involvement in disease
Sudden infant death with dysgenesis of the testes syndrome (SIDDT):
Autosomal recessive disorder. Affected infants appear normal at birth, develop signs of visceroautonomic dysfunction early in life, and die before 12 months of age of abrupt cardiorespiratory arrest. Features included bradycardia, hypothermia, severe gastroesophageal reflux, laryngospasm, bronchospasm, and abnormal cardiorespiratory patterns during sleep. Genotypic males with SIDDT had fetal testicular dysgenesis and ambiguous genitalia, with findings such as intraabdominal testes, dysplastic testes, deficient fetal testosterone production, fusion and rugation of the gonadal sac, and partial development of the penile shaft. Female sexual development was normal. Affected infants had an unusual staccato cry, similar to the cry of a goat.
PTM
Ubiquitinated by the CRL2(APPBP2) complex, which recognizes the Arg-Xaa-Xaa-Gly sequence at the C-terminus, leading to its degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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