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Mouse Anti-TTC3 Recombinant Antibody (CBYJT-5125) (CBMAB-T4703-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TTC3 (Tetratricopeptide Repeat Domain 3). The antibody can be used for immunoassay techniques, such as ELISA.
See all TTC3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5125
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa1-110 from human TTC3 (NP_003307) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-110

Target

Full Name
tetratricopeptide repeat domain 3
Introduction
TTC3 (Tetratricopeptide Repeat Domain 3) is a Protein Coding gene. Diseases related to TTC3 include Retinitis Pigmentosa 58 and Down Syndrome. Gene Ontology (GO) annotations related to TTC3 include ligase activity and ubiquitin-protein transferase activity. An important paralog of TTC3 is DZIP3.
Entrez Gene ID
7267
UniProt ID
P53804
Alternative Names
Tetratricopeptide Repeat Domain 3; RING-Type E3 Ubiquitin Transferase TTC3; Tetratricopeptide Repeat Protein 3; RING Finger Protein 105; TPR Repeat Protein 3; TPR Repeat Protein D; RNF105
Function
E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809).
Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950).
Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950).
Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809).
Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496).
Inhibits cell proliferation (PubMed:30203323).
Biological Process
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm
Golgi apparatus
Nuclear localization may be dependent on the proteolytic cleavage of full length protein in the cytoplasm (PubMed:30203323).
This cleavage may reveal an N-terminal nuclear localization signal, allowing N-terminal fragments to enter the nucleus (PubMed:30203323).
PTM
Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.
Proteolytically cleaved into differently sized N- and C-terminal fragments.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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