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Mouse Anti-TTLL1 Recombinant Antibody (CBYJT-5161) (CBMAB-T4739-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TTLL1 (Tubulin Tyrosine Ligase Like 1). The antibody can be used for immunoassay techniques, such as ELISA.
See all TTLL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5161
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
TTLL1 (AAH14968, 1 a.a. ~ 423 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAGKVKWVTD IEKSVLINNF EKRGWVQVTE NEDWNFYWMS VQTIRNVFSV EAGYRLSDDQ IVNHFPNHYE LTRKDLMVKN IKRYRKELEK EGSPLAEKDE NGKYLYLDFV PVTYMLPADY NLFVEEFRKS PSSTWIMKPC GKAQGKGIFL INKLSQIKKW SRDSKTSSFV SQSNKEAYVI SLYINNPLLI GGRKFDLRLY VLVSTYRPLR CYMYKLGFCR FCTVKYTPST SELDNMFVHP TNVAIQKHGE DYNHIHGGKW TVSNLRLYLE STRGKEVTSK LFDEIHWIIV QSLKAVAPVM NNDKHCFECY GYDIIIDDKL KPWLIEVNAS PSLTSSTAND RILKYNLIND TLNIAVPNGE IPDCKWNKSP PKEVLGNYEI LYDEELAQGD GADRELRSRQ GQSLGPRAGR SRDSGRAVLT TWK
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-423

Target

Full Name
tubulin tyrosine ligase-like family, member 1
Introduction
TTLL1 (Tubulin Tyrosine Ligase Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to TTLL1 include tubulin-glutamic acid ligase activity. An important paralog of TTLL1 is TTLL9.
Entrez Gene ID
25809
UniProt ID
O95922
Alternative Names
Tubulin Tyrosine Ligase Like 1; Tubulin Polyglutamylase Complex Subunit 3; Tubulin--Tyrosine Ligase-Like Protein 1; C22orf7; PGs3; Catalytic Subunit Of Neural Tubulin Polyglutamylase; Tubulin Tyrosine Ligase-Like Family, Member 1
Function
Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:34782749).
Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Biological Process
Biological Process cerebellar Purkinje cell differentiation Source:Ensembl
Biological Process immune response in nasopharyngeal-associated lymphoid tissue Source:Ensembl
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process mucociliary clearance Source:Ensembl
Biological Process protein polyglutamylation Source:GO_Central1 Publication
Biological Process regulation of blastocyst development Source:Ensembl
Biological Process sperm axoneme assembly Source:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, cilium basal body
Cytoplasm, cytoskeleton, cilium axoneme
Cell projection, cilium, flagellum
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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