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Mouse Anti-UBAP1 Recombinant Antibody (CBFYU-040) (CBMAB-U0040-FY)

This product is mouse antibody that recognizes UBAP1. The antibody CBFYU-040 can be used for immunoassay techniques such as: WB.
See all UBAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-040
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human BAP1 protein expressed and purified from E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin-associated protein 1
Introduction
Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2.
Entrez Gene ID
51271
UniProt ID
Q9NZ09
Alternative Names
NAG20; UAP; UBAP; UBAP-1
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368).
Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001).
Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368).
Biological Process
Biological Process membrane fission Source:ComplexPortal1 Publication
Biological Process multivesicular body assembly Source:ComplexPortal1 Publication
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source:ComplexPortal1 Publication
Biological Process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytosol
Endosome
Predominantly cytosolic (PubMed:21757351).
Recruited to endosomes as part of the ESCRT-I complex (PubMed:21757351).
Involvement in disease
Spastic paraplegia 80, autosomal dominant (SPG80):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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