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Mouse Anti-UBE2G2 Recombinant Antibody (5E1) (CBMAB-A9714-LY)

The product is antibody recognizes UBE2G2. The antibody 5E1 immunoassay techniques such as: WB, ELISA.
See all UBE2G2 antibodies
Published Data
Fig. 1 Cell lysates were harvested 48 h after transfection and immunoprecipitated with FLAG-resin and immunoblotted for Myc, ataxin-3, Ubc7, and FLAG. WB, Western blot.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
5E1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
UBE2G2 (NP_003329, 1 a.a. ~ 87 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ubiquitin Conjugating Enzyme E2 G2
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
7327
UniProt ID
P60604
Alternative Names
UBC7
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386).
In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).
Involved in endoplasmic reticulum-associated degradation (ERAD) (PubMed:22607976).
Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation (PubMed:23223569).
Biological Process
Biological Process cellular response to interferon-beta Source:UniProtKB1 Publication
Biological Process negative regulation of retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Endoplasmic reticulum
Lipid droplet
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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