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Mouse Anti-UBE3A Monoclonal Antibody (1A2) (CBMAB-0283-LY)

This product is mouse monoclonal antibody recognizes UBE3A of human. The antibody 1A2 immunoassay techniques such as: MA, IP, WB.
Host Species
Mouse
Application
IP, MA, WB
Immunogen
Recombinant peptide (Full Length)
Antibody Isotype
IgG1
Specificity
Human
Clone
1A2
Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses.
Alternative Name
ANCR; AS; E6-AP; EPVE6AP; FLJ26981; HPVE6A
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0283-LY
Conjugates
Size
Price $
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Second antibody and isotype control