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Mouse Anti-UBL4A Recombinant Antibody (CBFYU-181) (CBMAB-U0181-FY)

This product is mouse antibody that recognizes UBL4A. The antibody CBFYU-181 can be used for immunoassay techniques such as: IF, WB.
See all UBL4A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-181
Antibody Isotype
IgG2a
Application
IF, WB

Basic Information

Immunogen
Full length human recombinant protein of human UBL4A (NP_055050) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.19 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Like 4A
Introduction
GdX, also named ubiquitin-like protein 4A, is a ubiquitin-domain protein characterized by a ubiquitin-like domain that regulates the movement of misfolded proteins from the endoplasmic reticulum membrane to proteasome.
Entrez Gene ID
8266
UniProt ID
Q9Z2M13
Alternative Names
GDX; G6PD; GET5; MDY2; UBL4; TMA24; DX254E; DXS254E
Function
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892).
The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373).
Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892).
Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475).
The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).
Biological Process
Biological Process post-translational protein targeting to endoplasmic reticulum membrane Source:ComplexPortal1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process regulation of protein stability Source:ComplexPortal1 Publication
Biological Process tail-anchored membrane protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:ComplexPortal1 Publication
Cellular Location
Cytoplasm, cytosol
Nucleus
PTM
Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT3 complex and SGTA and therefore may regulate client proteins fate.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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