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Mouse Anti-UBR1 Recombinant Antibody (CBFYU-223) (CBMAB-U0223-FY)

This product is mouse antibody that recognizes UBR1. The antibody CBFYU-223 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all UBR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-223
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin protein ligase E3 component n-recognin 1
Introduction
This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.
Entrez Gene ID
197131
UniProt ID
Q8IWV7
Alternative Names
JBS
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Biological Process
Biological Process cellular response to leucine Source:UniProtKB1 Publication
Biological Process negative regulation of TOR signaling Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process via the N-end rule pathway Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Johanson-Blizzard syndrome (JBS):
This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and intellectual disability. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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