Mouse Anti-UchL1 Recombinant Antibody (SPM574) (CBMAB-P3769-YC)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity).
The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865).
Biological Process axon target recognition Source:Ensembl
Biological Process axonal transport of mitochondrion Source:Ensembl
Biological Process cellular response to xenobiotic stimulus Source:Ensembl
Biological Process eating behavior Source:Ensembl
Biological Process male germ cell proliferation Source:Ensembl
Biological Process muscle cell development Source:Ensembl
Biological Process negative regulation of MAP kinase activity Source:BHF-UCL1 Publication
Biological Process neuromuscular process Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process response to ischemia Source:Ensembl
Biological Process sensory perception of pain Source:Ensembl
Endoplasmic reticulum membrane
About 30% of total UCHL1 is associated with membranes in brain.
A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.
Spastic paraplegia 79, autosomal recessive (SPG79):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG79 is characterized by childhood onset blindness, cerebellar ataxia, nystagmus, dorsal column dysfunction, and spasticity with upper motor neuron dysfunction.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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