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Mouse Anti-UGT2B7 Recombinant Antibody (8D12) (CBMAB-C4566-CN)

This product is a Mouse antibody that recognizes UGT2B7. The antibody 8D12 can be used for immunoassay techniques such as: ELISA, WB.
See all UGT2B7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8D12
Application
ELISA, WB

Basic Information

Immunogen
UGT2B7 (NP_001065, aa 69-157) partial recombinant protein with GST tag
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4

Target

Full Name
UDP glucuronosyltransferase 2 family, polypeptide B7
Introduction
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Entrez Gene ID
7364
UniProt ID
P16662
Alternative Names
UDP Glucuronosyltransferase Family 2 Member B7; 3,4-Catechol Estrogen-Specific UDPGT; UDP-Glucuronosyltransferase 2B9; EC 2.4.1.17; UDPGT 2B7; UDPGT 2B9; UDPGTh-2; UDP Glucuronosyltransferase 2 Family, Polypeptide B7; UDP Glycosyltransferase 2 Family, Polypeptide B7;
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10702251, PubMed:15472229, PubMed:15470161, PubMed:18674515, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:23756265, PubMed:26220143, PubMed:17442341).
Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15470161, PubMed:18674515, PubMed:23756265).
Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:2159463, PubMed:15472229, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:26220143, PubMed:17442341).
Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development (PubMed:10702251).
Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265).
Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515).
Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161).
Biological Process
Biological Process androgen metabolic process Source:UniProtKB1 Publication
Biological Process cellular glucuronidation Source:UniProtKB3 Publications
Biological Process estrogen metabolic process Source:UniProtKB1 Publication
Biological Process lipid metabolic process Source:ProtInc1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Helical: 493-509
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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