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Mouse Anti-UNC13D Recombinant Antibody (1F4) (CBMAB-C4657-CN)

This product is a Mouse antibody that recognizes UNC13D. The antibody 1F4 can be used for immunoassay techniques such as: WB.
See all UNC13D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F4
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human UNC13D (NP_954712) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
unc-13 homolog D (C. elegans)
Introduction
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
Entrez Gene ID
201294
UniProt ID
Q70J99
Alternative Names
Unc-13 Homolog D; Munc13-4; Unc-13 Homolog D (C. Elegans); Protein Unc-13 Homolog D; HPLH3; FHL3; HLH3;
Function
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.
Biological Process
Biological Process defense response to virus Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process granuloma formation Source:Ensembl
Biological Process natural killer cell degranulation Source:Ensembl
Biological Process phagocytosis Source:Ensembl
Biological Process positive regulation of exocytosis Source:UniProtKB2 Publications
Biological Process positive regulation of regulated secretory pathway Source:UniProtKB1 Publication
Biological Process positive regulation of substrate adhesion-dependent cell spreading Source:Ensembl
Biological Process regulation of mast cell degranulation Source:UniProtKB1 Publication
Biological Process secretion Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Membrane
Late endosome
Recycling endosome
Lysosome
Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Involvement in disease
Hemophagocytic lymphohistiocytosis, familial, 3 (FHL3):
A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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