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Mouse Anti-UNKL Recombinant Antibody (F-8) (CBMAB-C4689-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
F-8
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 586-680 mapping at the C-terminus of UNKL of human origin
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Unkempt Family Like Zinc Finger
Introduction
This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Entrez Gene ID
64718
UniProt ID
Q9H9P5
Alternative Names
Unkempt Family Like Zinc Finger; Zinc Finger CCCH Domain-Containing Protein 5-Like; RING Finger Protein Unkempt-Like; Unkempt Family Zinc Finger-Like; C16orf28; ZC3HDC5L; ZC3H5L;
Function
May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.
Biological Process
Biological Process protein ubiquitination Source:UniProtKB-UniPathway
Cellular Location
Isoform 4
Cytoplasm
Nucleus
Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.
PTM
Isoform 4 is ubiquitinated in the C-terminal. Ubiquitination is enhanced by activated RAC1. The presence of the RING finger domain is not essential for ubiquitination to occur.
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For research use only. Not intended for any clinical use.

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