Rabbit Anti-UPK3A Recombinant Antibody (SP73) (CBMAB-C4710-CN)

Name: Rabbit Anti-UPK3A Recombinant Antibody (SP73)
SKU: CBMAB-C4710-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

SP73

Application

IHC-P

Immunogen

Synthetic peptide corresponding to C-terminus of human uroplakin III protein

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, 1% BSA, pH 7.6

Preservative

0.1% Sodium azide

More Infomation

Target

Full Name

Uroplakin 3A

Introduction

This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Entrez Gene ID

7380

UniProt ID

O75631

Alternative Names

Uroplakin 3A; Uroplakin III; Uroplakin 3; UPIII; UP3A; UPK3; Uroplakin-3a; UPIIIA;

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

Biological Process

Biological Process cell morphogenesis Source:Ensembl
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process kidney development Source:Ensembl
Biological Process potassium ion homeostasis Source:Ensembl
Biological Process sodium ion homeostasis Source:Ensembl
Biological Process urea transport Source:GO_Central1 Publication
Biological Process urinary bladder development Source:Ensembl
Biological Process water transport Source:GO_Central1 Publication

Cellular Location

Endoplasmic reticulum membrane
Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).

Involvement in disease

Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.

Topology

Lumenal: 19-207
Helical: 208-235
Cytoplasmic: 236-287

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-UPK3A Recombinant Antibody (SFI-1) (CAT#: CBMAB-C4709-CN)

Mouse Anti-UPK3A Recombinant Antibody (AU1) (CAT#: CBMAB-C4706-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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