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Mouse Anti-UQCRQ Recombinant Antibody (1H9DE5DG5BC8) (CBMAB-C4740-CN)

This product is a Mouse antibody that recognizes UQCRQ. The antibody 1H9DE5DG5BC8 can be used for immunoassay techniques such as: WB, FC.
See all UQCRQ antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Cattle, Human
Clone
1H9DE5DG5BC8
Antibody Isotype
IgG2a
Application
WB, FC

Basic Information

Immunogen
Bovine Complex III subunit 8 (UQCRQ)
Specificity
Mouse, Rat, Cattle, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
Ubiquinol-Cytochrome C Reductase Complex III Subunit VII
Introduction
This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human27089
Mouse22272
Rat497902
Cattle286885
UniProt ID
HumanO14949
MouseQ9CQ69
RatQ7TQ16
CattleP13271
Alternative Names
Ubiquinol-Cytochrome C Reductase Complex III Subunit VII; Complex III Subunit 8; Ubiquinol-Cytochrome C Reductase Complex Ubiquinone-Binding Protein QP-C; Ubiquinol-Cytochrome C Reductase, Complex III Subunit VII, 9.5kDa; Ubiquinol-Cytochrome C Reductase Complex 9.5 KDa Protein; Complex III Subunit VIII; Ubiquinol-Cytochrome C Reductase, Complex III Subunit VII; Low Molecular Mass Ubiquinone-Binding Protein (9.5kD);
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Biological Process
Biological Process cellular respiration Source:ComplexPortal1 Publication
Biological Process cerebellar Purkinje cell layer development Source:Ensembl
Biological Process hippocampus development Source:Ensembl
Biological Process hypothalamus development Source:Ensembl
Biological Process midbrain development Source:Ensembl
Biological Process mitochondrial electron transport, ubiquinol to cytochrome c Source:GO_Central1 Publication
Biological Process pons development Source:Ensembl
Biological Process pyramidal neuron development Source:Ensembl
Biological Process subthalamus development Source:Ensembl
Biological Process thalamus development Source:Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Mitochondrial complex III deficiency, nuclear 4 (MC3DN4):
A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.
Topology
Mitochondrial matrix: 2-39
Helical: 40-68
Mitochondrial intermembrane: 69-82
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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