Mouse Anti-UQCRQ Recombinant Antibody (1H9DE5DG5BC8) (CBMAB-C4740-CN)

Name: Mouse Anti-UQCRQ Recombinant Antibody (1H9DE5DG5BC8)
SKU: CBMAB-C4740-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1H9DE5DG5BC8

Application

WB, FC

Immunogen

Bovine Complex III subunit 8 (UQCRQ)

Specificity

Mouse, Rat, Cattle, Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Ubiquinol-Cytochrome C Reductase Complex III Subunit VII

Introduction

This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	27089
Mouse	22272
Rat	497902
Cattle	286885

UniProt ID

Human	O14949
Mouse	Q9CQ69
Rat	Q7TQ16
Cattle	P13271

Alternative Names

Ubiquinol-Cytochrome C Reductase Complex III Subunit VII; Complex III Subunit 8; Ubiquinol-Cytochrome C Reductase Complex Ubiquinone-Binding Protein QP-C; Ubiquinol-Cytochrome C Reductase, Complex III Subunit VII, 9.5kDa; Ubiquinol-Cytochrome C Reductase Complex 9.5 KDa Protein; Complex III Subunit VIII; Ubiquinol-Cytochrome C Reductase, Complex III Subunit VII; Low Molecular Mass Ubiquinone-Binding Protein (9.5kD);

Function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.

Biological Process

Biological Process cellular respiration Source:ComplexPortal1 Publication
Biological Process cerebellar Purkinje cell layer development Source:Ensembl
Biological Process hippocampus development Source:Ensembl
Biological Process hypothalamus development Source:Ensembl
Biological Process midbrain development Source:Ensembl
Biological Process mitochondrial electron transport, ubiquinol to cytochrome c Source:GO_Central1 Publication
Biological Process pons development Source:Ensembl
Biological Process pyramidal neuron development Source:Ensembl
Biological Process subthalamus development Source:Ensembl
Biological Process thalamus development Source:Ensembl

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Mitochondrial complex III deficiency, nuclear 4 (MC3DN4):
A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.

Topology

Mitochondrial matrix: 2-39
Helical: 40-68
Mitochondrial intermembrane: 69-82

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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