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Mouse Anti-URM1 Recombinant Antibody (182CT27.2.2) (CBMAB-C4745-CN)

This product is a Mouse antibody that recognizes URM1. The antibody 182CT27.2.2 can be used for immunoassay techniques such as: ELISA, WB.
See all URM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
182CT27.2.2
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
URM1 recombinant protein
Specificity
Human
Antibody Isotype
IgM, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide

Target

Full Name
Ubiquitin Related Modifier 1
Introduction
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Entrez Gene ID
81605
UniProt ID
Q9BTM9
Alternative Names
Ubiquitin Related Modifier 1; C9orf74; Ubiquitin Related Modifier 1 Homolog (S. Cerevisiae); Ubiquitin-Related Modifier 1 Homolog; Chromosome 9 Open Reading Frame 74; Ubiquitin-Related Modifier 1;
Function
Acts as a sulfur carrier required for 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm5S2U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Biological Process
Biological Process protein urmylation Source:GO_Central1 Publication
Biological Process tRNA thio-modification Source:UniProtKB1 Publication
Biological Process tRNA wobble uridine modification Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm
Mitochondrion
Cell projection, dendrite
Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
PTM
C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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