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Rabbit Anti-USP18 Recombinant Antibody (CBXU-011) (CBMAB-U0127-CQ)

This product is a rabbit antibody that recognizes USP18. The antibody CBXU-011 can be used for immunoassay techniques such as: IP, WB.
See all USP18 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXU-011
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Pro45 of human USP18 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 18
Introduction
This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease.
Entrez Gene ID
11274
UniProt ID
Q9UMW8
Alternative Names
ISG43; UBP43; PTORCH2
Function
Involved in the negative regulation of the inflammatory response triggered by type I interferon (PubMed:28165510, PubMed:27325888).
Upon recruitment by STAT2 to the type I IFN receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I IFN signaling pathway (PubMed:28165510).
Also regulates protein ISGylation. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms (PubMed:11788588).
Isoform 2
Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061).
Biological Process
Biological Process negative regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:GO_Central1 Publication
Biological Process regulation of inflammatory response Source:UniProtKB1 Publication
Biological Process response to bacterium Source:Ensembl
Biological Process response to stilbenoid Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Isoform 1
Cytoplasm
Isoform 2
Nucleus
Cytoplasm
Involvement in disease
Pseudo-TORCH syndrome 2 (PTORCH2):
An autosomal recessive multisystem disorder characterized by antenatal onset of intracranial hemorrhage, calcification, brain malformations, liver dysfunction, and often thrombocytopenia. Affected individuals tend to have respiratory insufficiency and seizures, and die in infancy. The phenotype resembles the sequelae of intrauterine infection, but there is no evidence of an infectious agent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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