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Rabbit Anti-USP19 Recombinant Antibody (CBXU-023) (CBMAB-U0139-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXU-023
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.271 mg/mL
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 19
Introduction
This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
10869
UniProt ID
O94966
Alternative Names
ZMYND9
Function
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.
Biological Process
Biological Process negative regulation of skeletal muscle tissue development Source:UniProtKB
Biological Process positive regulation of cell cycle process Source:UniProtKB
Biological Process protein deubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein stabilization Source:ParkinsonsUK-UCL1 Publication
Biological Process regulation of cellular response to hypoxia Source:UniProtKB1 Publication
Biological Process regulation of ERAD pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process regulation of protein stability Source:UniProtKB
Biological Process response to endoplasmic reticulum stress Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-1291
Helical: 1292-1312
Lumenal: 1313-1318
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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