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Mouse Anti-USP2 (aa 1-258) Recombinant Antibody (CBXU-054) (CBMAB-U0167-CQ)

This product is a mouse antibody that recognizes USP2 (aa 1-258). The antibody CBXU-054 can be used for immunoassay techniques such as: ELISA, WB.
See all USP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
CBXU-054
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-258 from human USP2
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-258

Target

Full Name
Ubiquitin Specific Peptidase 2
Introduction
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling.
Entrez Gene ID
Human9099
Monkey705191
UniProt ID
HumanO75604
MonkeyF7DHN5
Alternative Names
USP9; UBP41
Function
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211).
Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity).
Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211).
Has no deubiquitinase activity against p53/TP53 (PubMed:17290220).
Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220).
Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254).
Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity).
Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity).
Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity).
Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity).
Isoform 4
Circadian clock output effector that regulates Ca2+ absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca2+ membrane permeability mediated by the Ca2+ channel TRPV6 in the intestine.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process circadian behavior Source:UniProtKB
Biological Process circadian regulation of gene expression Source:UniProtKB
Biological Process entrainment of circadian clock by photoperiod Source:UniProtKB
Biological Process locomotor rhythm Source:UniProtKB
Biological Process muscle organ development Source:UniProtKB-KW
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB2 Publications
Biological Process protein stabilization Source:UniProtKB1 Publication
Biological Process regulation of signal transduction by p53 class mediator Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.
Isoform 4
Nucleus
Membrane
Cytoplasm
Predominantly expressed at membranes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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