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Mouse Anti-USP20 (aa 252-349) Recombinant Antibody (1A6) (CBMAB-U0013-CQ)

This product is a mouse antibody that recognizes USP20 (aa 252-349). The antibody 1A6 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all USP20 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A6
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Immunogen
Partial recombinant corresponding to amino acids 252-349 from human USP20 (NP_001008563)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 252-349

Target

Full Name
ubiquitin specific peptidase 20
Introduction
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex.
Entrez Gene ID
10868
UniProt ID
Q9Y2K6
Alternative Names
VDU2; hVDU2; LSFR3A
Function
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Biological Process
Biological Process endocytosis Source:UniProtKB-KW
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein K63-linked deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
PTM
Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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