Sign in or Register   Sign in or Register
  |  

Mouse Anti-USP34 (aa 3296-3395) Recombinant Antibody (2E2) (CBMAB-U0052-CQ)

This product is a mouse antibody that recognizes USP34 (aa 3296-3395). The antibody 2E2 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB.
See all USP34 antibodies
Published Data
Fig.1 USP34 is a DNA damage-responsive protein.
...View More
Fig.2 Cells were processed for immunofluorescence experiments using indicated antibodies, and the percentage of USP34 foci-positive cells before and after IR is plotted.
...View More
Fig.3 USP34 promotes RNF168 protein stability.
...View More
Fig.4 USP34 counteracts IR-induced RNF168 ubiquitylation.
...View More
Fig.5 Validation of Cav-1 (P132L)-induced gene products by Western blot analysis.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E2
Antibody Isotype
IgG2a, к
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to amino acids 3296-3395 from USP34 (NP_055524)
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
None
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 3296-3395

Target

Full Name
ubiquitin specific peptidase 34
Introduction
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway.
Entrez Gene ID
9736
UniProt ID
Q70CQ2
Alternative Names
USP34; ubiquitin specific peptidase 34; ubiquitin specific protease 34; ubiquitin carboxyl-terminal hydrolase 34; KIAA0570; KIAA0729; ubiquitin thioesterase 34; deubiquitinating enzyme 34; ubiquitin thiolesterase 34; ubiquitin-specific-processing protease 34; FLJ43910; MGC104459
Function
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Biological Process
Biological Process positive regulation of canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:FlyBase1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Biological Process Wnt signaling pathway Source:Reactome
Cellular Location
cytosol
nucleus
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-USP34 (aa 3296-3395) Recombinant Antibody (2E2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare