Mouse Anti-USP34 (aa 3296-3395) Recombinant Antibody (2E2) (CBMAB-U0052-CQ)

Name: Mouse Anti-USP34 (aa 3296-3395) Recombinant Antibody (2E2)
SKU: CBMAB-U0052-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

2E2

Application

ELISA, IF, IHC, WB

Immunogen

Partial recombinant corresponding to amino acids 3296-3395 from USP34 (NP_055524)

Specificity

Human

Antibody Isotype

IgG2a, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

None

Purity

>95% as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 3296-3395

More Infomation

Target

Full Name

ubiquitin specific peptidase 34

Introduction

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway.

Entrez Gene ID

9736

UniProt ID

Q70CQ2

Alternative Names

USP34; ubiquitin specific peptidase 34; ubiquitin specific protease 34; ubiquitin carboxyl-terminal hydrolase 34; KIAA0570; KIAA0729; ubiquitin thioesterase 34; deubiquitinating enzyme 34; ubiquitin thiolesterase 34; ubiquitin-specific-processing protease 34; FLJ43910; MGC104459

Function

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Biological Process

Biological Process positive regulation of canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:FlyBase1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Biological Process Wnt signaling pathway Source:Reactome

Cellular Location

cytosol
nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-USP34 Recombinant Antibody (CBXU-099) (CAT#: CBMAB-U0197-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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