Mouse Anti-USP45 (aa 106-197) Recombinant Antibody (1H2) (CBMAB-U0038-CQ)

Name: Mouse Anti-USP45 (aa 106-197) Recombinant Antibody (1H2)
SKU: CBMAB-U0038-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

1H2

Application

ELISA, IHC-P, WB

Immunogen

Partial recombinant corresponding to amino acids 106-197 from human USP45 (XP_371838)

Specificity

Human

Antibody Isotype

IgG2a, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

None

Purity

>95% as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 106-197

More Infomation

Target

Full Name

ubiquitin specific peptidase 45

Introduction

The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease.

Entrez Gene ID

85015

UniProt ID

Q70EL2

Alternative Names

USP45; ubiquitin specific peptidase 45; ubiquitin specific protease 45; ubiquitin carboxyl-terminal hydrolase 45; MGC14793; ubiquitin thioesterase 45; deubiquitinating enzyme 45; ubiquitin thiolesterase 45; ubiquitin-specific-processing protease 45

Function

Catalyzes the deubiquitination of SPDL1 (PubMed:30258100).
Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220).
May be involved in the maintenance of photoreceptor function (PubMed:30573563).
May play a role in normal retinal development (By similarity).
Plays a role in cell migration (PubMed:30258100).

Biological Process

Biological Process cell migration Source:UniProtKB1 Publication
Biological Process DNA repair Source:MGI1 Publication
Biological Process global genome nucleotide-excision repair Source:Reactome
Biological Process neural retina development Source:UniProtKB
Biological Process photoreceptor cell maintenance Source:UniProtKB
Biological Process protein deubiquitination Source:FlyBase1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Photoreceptor inner segment
Cytoplasm
Nucleus

Involvement in disease

Leber congenital amaurosis 19 (LCA19):
A form of Leber congenital amaurosis, a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. LCA19 is an autosomal recessive form characterized by reduced vision in early childhood and severely reduced responses of both rods and cones.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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