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Mouse Anti-USP45 (aa 106-197) Recombinant Antibody (1H2) (CBMAB-U0038-CQ)

This product is a mouse antibody that recognizes USP45 (aa 106-197). The antibody 1H2 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all USP45 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H2
Antibody Isotype
IgG2a, к
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Partial recombinant corresponding to amino acids 106-197 from human USP45 (XP_371838)
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
None
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 106-197

Target

Full Name
ubiquitin specific peptidase 45
Introduction
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease.
Entrez Gene ID
85015
UniProt ID
Q70EL2
Alternative Names
USP45; ubiquitin specific peptidase 45; ubiquitin specific protease 45; ubiquitin carboxyl-terminal hydrolase 45; MGC14793; ubiquitin thioesterase 45; deubiquitinating enzyme 45; ubiquitin thiolesterase 45; ubiquitin-specific-processing protease 45
Function
Catalyzes the deubiquitination of SPDL1 (PubMed:30258100).
Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220).
May be involved in the maintenance of photoreceptor function (PubMed:30573563).
May play a role in normal retinal development (By similarity).
Plays a role in cell migration (PubMed:30258100).
Biological Process
Biological Process cell migration Source:UniProtKB1 Publication
Biological Process DNA repair Source:MGI1 Publication
Biological Process global genome nucleotide-excision repair Source:Reactome
Biological Process neural retina development Source:UniProtKB
Biological Process photoreceptor cell maintenance Source:UniProtKB
Biological Process protein deubiquitination Source:FlyBase1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Photoreceptor inner segment
Cytoplasm
Nucleus
Involvement in disease
Leber congenital amaurosis 19 (LCA19):
A form of Leber congenital amaurosis, a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. LCA19 is an autosomal recessive form characterized by reduced vision in early childhood and severely reduced responses of both rods and cones.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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