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Mouse Anti-USP5 Recombinant Antibody (2H5) (CBMAB-U0059-CQ)

This product is a mouse antibody that recognizes USP5. The antibody 2H5 can be used for immunoassay techniques such as: IHC, IHC-P, WB.
See all USP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey, Rat
Clone
2H5
Antibody Isotype
IgG2a
Application
IHC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human USP5 produced in HEK293T cell
Specificity
Human, Dog, Monkey, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 5
Introduction
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins.
Entrez Gene ID
Human8078
Monkey714032
Rat297593
Dog486718
UniProt ID
HumanP45974
MonkeyF7CT78
RatD3ZVQ0
DogA0A8C0P3K1
Alternative Names
ISOT
Function
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Biological Process
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
cytosol
lysosome
nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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