USP5
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
Full Name
Ubiquitin Specific Peptidase 5
Function
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Biological Process
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Biological Process protein deubiquitination Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
cytosol
lysosome
nucleus
lysosome
nucleus
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Anti-USP5 antibodies
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CompareTarget: USP5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF468
Application*: ELISA, WB
Target: USP5
Host: Mouse
Specificity: Human
Clone: CBFYU-260
Application*: WB, IH, E
Target: USP5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXU-103
Application*: E, WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXU-048
Application*: WB
Target: USP5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXU-019
Application*: WB, F, IC
Target: USP5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXU-018
Application*: WB, IP
Target: USP5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G4
Application*: E, WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey, Rat
Clone: 2H5
Application*: IH, P, WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F5
Application*: IC, IH, P, WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey, Rat
Clone: 2E3
Application*: IH, P, WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C8
Application*: E, WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F9
Application*: WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey, Rat
Clone: 1F8
Application*: IH, P, WB
Target: USP5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A8
Application*: IH, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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