Mouse Anti-UTP4 Recombinant Antibody (CBFYC-3215) (CBMAB-C3292-FY)

Name: Mouse Anti-UTP4 Recombinant Antibody (CBFYC-3215)
SKU: CBMAB-C3292-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYC-3215

Application

Dot, ICC

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

UTP4, SMALL SUBUNIT PROCESSOME COMPONENT

Introduction

This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

84916

UniProt ID

Q969X6

Alternative Names

UTP4, Small Subunit Processome Component; Cirrhosis, Autosomal Recessive 1A (Cirhin); CIRHIN; CIRH1A; UTP4, Small Subunit (SSU) Processome Component, Homolog (Yeast); UTP4, Small Subunit (SSU) Processome Component, Homolog; U3 Small Nucleolar RNA-Associated Protein 4 Homolog; UTP4 Small Subunit (SSU) Processome Component

Function

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766).
May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).

Biological Process

Biological Process maturation of SSU-rRNA Source:UniProtKB1 Publication
Biological Process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source:GO_Central1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication

Cellular Location

Nucleus, nucleolus
Chromosome
Found predominantly at the fibrillar center.

PTM

May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15.1 Publi

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-UTP4 Recombinant Antibody (CBFYC-3216) (CAT#: CBMAB-C3293-FY)

Isotype control

For research use only. Not intended for any clinical use.

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