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Mouse Anti-UTP4 Recombinant Antibody (CBFYC-3215) (CBMAB-C3292-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-3215
Antibody Isotype
IgG1
Application
Dot, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
UTP4, SMALL SUBUNIT PROCESSOME COMPONENT
Introduction
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
84916
UniProt ID
Q969X6
Alternative Names
UTP4, Small Subunit Processome Component; Cirrhosis, Autosomal Recessive 1A (Cirhin); CIRHIN; CIRH1A; UTP4, Small Subunit (SSU) Processome Component, Homolog (Yeast); UTP4, Small Subunit (SSU) Processome Component, Homolog; U3 Small Nucleolar RNA-Associated Protein 4 Homolog; UTP4 Small Subunit (SSU) Processome Component
Function
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766).
May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).
Biological Process
Biological Process maturation of SSU-rRNA Source:UniProtKB1 Publication
Biological Process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source:GO_Central1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Cellular Location
Nucleus, nucleolus
Chromosome
Found predominantly at the fibrillar center.
PTM
May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15.1 Publi
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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